Publications

Publication List (2014-2024)

First-author papers

• • Ma C., Peng Y., Li H., Chen W.*, Organ-on-a-Chip: A new paradigm for drug development. Trends in Pharmacological Sciences, 2021, 42(2):119-133

  • Ma C., Witkowski M.T., Harris, J., Dolgalev I., Sreeram S., Qian W., Tong J., Chen X., Aifantis I., Chen W.*, Leukemia-on-a-Chip: Dissecting the chemo-resistance mechanisms in B-cell acute lymphoblastic leukemia (B-ALL) bone marrow niche. Science Advances, 2020, 6(45):eaba5536.

  • Ma C., Tian C., Zhao L., Wang J.*, Pneumatic-aided micro-molding for flexible fabrication of homogeneous and heterogeneous cell-laden microgels. Lab on a Chip, 2016, 16 (14):2609-2617 (Inside Front Cover; Selected as "Recent HOT Articles" by the journal).

  • Ma C., Zhao, L., Zhou, E.-M., Xu, J., Shen, S., Wang, J.*, On-Chip Construction of Liver Lobule-like Microtissue and Its Application for Adverse Drug Reaction Assay. Analytical Chemistry, 2016, 88(3):1719-1727 (Highlighted by ACS News Service Weekly PressPac, Science Daily, and Digital Journal).

  • Ma C., Shen S., Zhao L., Wang J.*, Multiscale applications of microfluidic chip in life science: from molecules to organisms. Journal of Instrumental Analysis, 2015, 34(3):246-256 (In Chinese).

Co-first-author papers

• • Liu L.†, Ma C.†, Zhang Z., Chen W.*, A computational model of CAR T-cell immunotherapy predicts leukemia patient responses at remission, resistance, and relapse. Journal for ImmunoTherapy of Cancer, 2022, 10:e005360.

  • Zhang Z.†, Liu L.†, Ma C.†, Chen W.*, An in silico glioblastoma microenvironment model dissects the immunological mechanisms of resistance to PD-1 checkpoint blockade immunotherapy. Small Methods, 2021, 2100197.

  • Cui X.†, Ma C.†, Vasudevaraja V., Serrano J., Tong J., Peng Y., Delorenzo M., Shen G., Frenster J., Morales R.T., Qian W., Tsirigos A., S Chi A.S., Jain R., Kurz S.C., Sulman E.P., Placantonakis D.G., Snuderl M., Chen W.*, Dissecting the Heterogeneity of Immunosuppressive Tumor Microenvironments in Glioblastoma-on-a-Chip to Optimize PD-1 Immunotherapy. eLife, 2020, 9:e52253.

  • An Y.†, Ma C.†, Tian C., Zhao L., Pang L., Tu Q., Xu J., Wang J.*, On-chip assay of the effect of topographical microenvironment on cell growth and cell-cell interactions during wound healing. Biomicrofluidics, 2015, 9(6):064112.

  • He J.†, Ma C.†, Liu W., Wang J.*, On-chip monitoring of skeletal myoblast transplantation for the treatment of hypoxia-induced myocardial injury. Analyst, 2014, 139(18):4482-4490.

Co-author papers

• • Ma B., Liu X., Zhang Z., Ma C., Patwardhan S., Chand R., Wang C., Gao Z., Yang W., Thamphiwatana S. D., Chen P., Chen W.*, A Digital Nanoplasmonic Biosensing Microarray for Cytokine Immunomonitoring during CAR T-Cell Therapy from Leukemia Tumor Microenvironment Model. Biosensors & Bioelectronics, 2023, 230: 115247.

  • Zhou L., Liu L., Chang M. A., Ma C., Chen W., Chen P.*, Spatiotemporal Dissection of Tumor Microenvironment via In-Situ Sensing and Monitoring in Tumor-on-a-Chip. Biosensors & Bioelectronics, 2023, 225:115064.

  • Witkowski M.T.†*, Lee S.†, Wang E.†, Lee A.K, Talbot A., Ma, C., Tsopoulidis N., Brumbaugh J., Zhao Y., Roberts, G.K., Hogg S.J., Nomikou S., Ghebrechristos Y., Thandapani P., Mullighan G.C., Hochedlinger K., Chen, W., Abdel-Wahab O., Eyquem J., Aifantis I.* NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia. Nature Immunology, 2022.

  • Li J.†, Hu D.†, Lim C. K., Ren J., Yao X., Ma C., Marcos, Chen W., Lee P. K. H., and Lam R. H. W.*, Selective Single-Bacteria Extraction Based on Microfluidic Emulsion and Sequential Droplet Capture. Scientific Reports, 2022, 12:15461.

  • Zhang Z., Liu L., Ma C., Chen W.*, A computational model of cytokine release syndrome during CAR T-cell therapy. Advanced Therapeutics, 2022, 2200130.

  • Li R., Ali W., Ma C., Varshney A., Rowe C.R., Bajpai A., Luu N.K., Chen W.*, Surface Decoration of Noncanonical Wnt5a Motif Promotes the Mechanotransduction and Activation of CD8+ Cytotoxic T Cell. ChemComm, 2021 ,57, 12667-12670.

  • Wang C., Huang C., Gao Z., Shen J., He J., MacLachlan, A., Ma C., Chang Y., Yang W., Cai Y., Lou Y., Dai S., Chen W., Li F., Chen P.*, Nanoplasmonic Sandwich Immunoassay for Tumor-Derived Exosome Detection and Exosomal PD-L1 Profiling. ACS Sensors, 2021, 6(9): 3308-3319.

  • Witkowski M.T.†*, Dolgalev I.†, Evensen N. A., Ma C., Chambers T., Roberts K.G., Sreeram S., Dai Y., Tikhonova A.N., Lasry A., Qu C., Pei, D., Cheng C., Robbins G. A., Pierro J. Selvaraj S., Mezzano V., Daves M., Lupo P.J., Scheurer M. E., Loomis C. A., Mullighan C. G., Chen W., Rabin K. R., Tsirigos A., Carroll W.L.*, Aifantis I.*, Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia. Cancer Cell, 2020, 37(6): 867-882.e12 (Front Cover).

  • Li R., Ma C., Cai H., Chen W.*, The CAR T-cell Mechanoimmunology at a Glance. Advanced Sciences, 2020, 2002628.

  • Witzel I., Nasser R., Garcia-Sabaté A., Sapudom J., Ma C., Chen W., Teo J.*, Deconstructing immune microenvironments of lymphoid tissues for reverse engineering. Advanced Healthcare Materials, 2019, 8, 1801126.

  • Cai Y., Zhu J., He J., Yang W., Ma C., Xiong F., Li F., Chen W., Chen P.*, Magnet Patterned Superparamagnetic Fe3O4/Au Core-Shell Nanoplasmonic Sensing Array for Label-Free High Throughput Cytokine Immunoassay. Advanced Healthcare Materials, 2019, 8, 1801478.

  • Liu W., Tian C., Yan M., Zhao L., Ma C., Xu J., Wang J.*, Heterotypic 3D tumor culture in a reusable platform using pneumatic microfluidics. Lab on a Chip, 2016, 16 (21):4106-4120 (Inside Front Cover).

  • Chen S., Ma C., Yuan M.-S., Wang W., Wang D.-E., Chen S.-W., Wang J.*, A dual functional probe: sensitive fluorescence response to H2S and colorimetric detection for SO32-. RSC Advances, 2016, 6 (88):85529-85537.

  • Tu Q., Ma C., Tian C., Yuan M., Han X., Wang D.-E., Cao C. Wang, J.*, Quantum dots modified with quaternized poly(dimethylaminoethyl methacrylate) for selective recognition and killing of bacteria over mammalian cells. Analyst, 2016, 141(11):3328-3336.

  • Zhao L., Ma C., Shen S., Tian C., Xu J., Tu Q., Li T., Wang Y., Wang J.*, Pneumatic microfluidics-based multiplex single-cell array. Biosensors & Bioelectronics, 2016, 78:423-430.

  • Yan J.-H., Zhao L., Shen S., Ma C., Wang J.*, Application Progress of Droplet-based Microfluidics in Biomedicine. Chinese Journal of Analytical Chemistry, 2016, 44(4):562-568 (In Chinese).

  • Xu J., Li T., Shen S., Zhao L., Ma C., Mahmoud A. E., Wang J.*, Electrochemically Reduced Carboxyl Graphene Modified Electrode for Simultaneous Determination of Guanine and Adenine. Analytical Letters, 2015, 48(9):1465-1480.

  • Wang Y., Zhao L., Tian C., Ma C., Wang J.*, Geometrically controlled preparation of various cell aggregates by droplet-based microfluidics. Analytical Methods, 2015, 7(23):10040-10051.

  • Wang J.-C., Liu W., Tu Q., Ma C., Zhao L., Wang Y., Ouyang J., Pang L., Wang J.*, High throughput and multiplex localization of proteins and cells for in situ micropatterning using pneumatic microfluidics. Analyst, 2015, 140(3):827-836.

  • Pang, L., Shen, S., Ma, C., Ma, T., Zhang, R., Tian, C., Zhao, L., Liu, W., Wang, J.*, Deformability and size-based cancer cell separation using an integrated microfluidic device. Analyst, 2015, 140(21):7335-7346.

  • Liu W., Xu J., Li, T., Zhao L., Ma C., Shen S., Wang J.*, Monitoring Tumor Response to Anticancer Drugs Using Stable Three-Dimensional Culture in a Recyclable Microfluidic Platform. Analytical Chemistry, 2015, 87(19):9752-9760.

  • Chen S., Ma C., Wang D.-E., Han X., Zhang L., Wang J.*, Highly sensitive and selective coumarin probe for hydrogen sulfide imaging in living cells. Analytical Methods, 2015, 7(18):7646-7652.

  • Zhang Y., Pang L., Ma C., Tu Q., Zhang R., Saeed E., Mahmoud A. E., Wang J.*, Small Molecule-Initiated Light-Activated Semiconducting Polymer Dots: An Integrated Nanoplatform for Targeted Photodynamic Therapy and Imaging of Cancer Cells. Analytical Chemistry, 2014, 86(6):3092-3099.

  • Shen S., Ma C., Zhao L., Wang Y., Wang J.-C., Xu J., Li T., Pang L., Wang J.*, High-throughput rare cell separation from blood samples using steric hindrance and inertial microfluidics. Lab on a Chip, 2014, 14(14):2525-2538.

Editorial

• • Ma C., Huang X., Wang Y., Shen S., Liu, W.*, Advanced Polymeric Materials and Nanomaterials Enabled Construction and Application of Biomedical Microdevices. Frontiers in Bioengineering and Biotechnology. 2022